Nginx+MySQL+PHP环境是按照张宴的文章搭建的，只需作一点修改就可以让Magento跑起来

1、修改fcgi.conf
vi /usr/local/webserver/nginx/conf/fcgi.conf
将
fastcgi_param  SCRIPT_FILENAME    $document_root$fastcgi_script_name;
fastcgi_param  SCRIPT_NAME        $fastcgi_script_name;
修改为
#fastcgi_param  SCRIPT_FILENAME    $document_root$fastcgi_script_name;
#fastcgi_param  SCRIPT_NAME        $fastcgi_script_name;

2、修改nginx.conf
mv /usr/local/webserver/nginx/conf/nginx.conf /usr/local/webserver/nginx/conf/nginx.conf.OLD
vi /usr/local/webserver/nginx/conf/nginx.conf
添加以下内容：

user  www www;
worker_processes 8;
pid        /usr/local/webserver/nginx/nginx.pid;
worker_rlimit_nofile 51200;

events
{
use epoll;
worker_connections 51200;
}

http
{
include       mime.types;
default_type  application/octet-stream;

#charset  gb2312;

server_names_hash_bucket_size 128;
client_header_buffer_size 32k;
large_client_header_buffers 4 32k;
client_max_body_size 8m;

sendfile on;
tcp_nopush     on;

keepalive_timeout 60;

tcp_nodelay on;

fastcgi_connect_timeout 300;
fastcgi_send_timeout 300;
fastcgi_read_timeout 300;
fastcgi_buffer_size 64k;
fastcgi_buffers 4 64k;
fastcgi_busy_buffers_size 128k;
fastcgi_temp_file_write_size 128k;

gzip on;
gzip_min_length  1k;
gzip_buffers     4 16k;
gzip_http_version 1.0;
gzip_comp_level 2;
gzip_types       text/plain application/x-javascript text/css application/xml;
gzip_vary on;

#limit_zone  crawler  $binary_remote_addr  10m;
server {
listen   80;
server_name  www.example.com;
index index.html index.htm index.php;
root  /data0/htdocs/www;
error_log  /data1/logs/nginx_error.log;

# media
location ~* \.(png|gif|jpg|jpeg|css|js|swf|ico)$ {
root   /data0/htdocs/www/;
access_log off;
expires 30d;
}

# pass the PHP scripts to FastCGI socket
location ~ \.php$ {
fastcgi_pass   127.0.0.1:9000;
fastcgi_index index.php;
fastcgi_param  SCRIPT_NAME $fastcgi_script_name;
fastcgi_param  SCRIPT_FILENAME /data0/htdocs/www$fastcgi_script_name;
include fcgi.conf;
}
location ^~ /js/proxy.php {
fastcgi_pass   127.0.0.1:9000;
fastcgi_index index.php;
fastcgi_param  SCRIPT_NAME $fastcgi_script_name;
fastcgi_param  SCRIPT_FILENAME  /data0/htdocs/www$fastcgi_script_name;
include fcgi.conf;
access_log off;
expires 30d;
}
location / {
fastcgi_pass  127.0.0.1:9000;
fastcgi_index index.php;
fastcgi_param  SCRIPT_NAME index.php;
fastcgi_param  SCRIPT_FILENAME /data0/htdocs/www/index.php;
include fcgi.conf;
}
}
}

请根据实际情况进行修改，如果按照张宴文章配置，则只需将server_name修改为你自己的域名，保存退出。
重启Nginx，使配置生效
kill -HUP `cat /usr/local/webserver/nginx/nginx.pid`

经过以上设置，就可以使Magento跑在Nginx上了。

主要参考文章：

http://blog.s135.com/nginx_php_v4/

http://www.magentocommerce.com/boards/viewthread/7931/

http://www.ruby-forum.com/topic/177888